"Investigation of ARMS2 and CFH Polymorphisms Associated with Age-Related Macular Degeneration in Alzheimer’s Disease Patients. A Greek Cohort Study"
نویسندگان
چکیده
The most common macular condition is called Age-related Macular Degeneration (AMD). It a neurodegenerative disease that leads to loss of central vision since the affected areas are main retina and choroid eye.
منابع مشابه
Investigation of associations of ARMS2, CD14, and TLR4 gene polymorphisms with wet age-related macular degeneration in a Greek population
BACKGROUND Age-related macular degeneration (AMD) is a multifactorial degenerative ocular disease that leads to loss of central vision. Functional gene polymorphisms have already been associated with the disease (for example, ARMS2 A69S, rs10490924). AIM The goal of our study was to verify the correlation of the aforementioned ARMS2 variation with the disease, to examine, for the first time, ...
متن کاملCFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration.
OBJECTIVE The Age-Related Eye Disease Study (AREDS) demonstrated that antioxidant and zinc supplementation decreases progression to advanced age-related macular degeneration (AMD) in patients with moderate to severe disease. We evaluated the interaction of genetics and type of nutritional supplement on progression from moderate to advanced AMD. DESIGN Genetic analysis of a randomized, prospec...
متن کاملInfluence of CFH, HTRA1 and ARMS2 haplotype polymorphisms in the development of age-related macular disease.
OBJECTIVE To demonstrate genetic influence on the onset of age-related macular disease (AMD), analyzing genotype distribution of haplotypes, including polymorphisms of genes with proved relationships with AMD risk (CFH, ARMS2, HTRA1) in patients with AMD and in healthy people. METHODS We took 101 consecutive patients with an AMD diagnosis following Wisconsin international classification. For ...
متن کاملJoint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population
Purpose. The etiology of neovascular age-related macular degeneration (nAMD) cannot be completely explained by identified environmental risk factors or single-locus gene variants. This study was to explore the potential interactions among gene variants on nAMD in Chinese population. Methods. 43 SNPs located in different genes were genotyped in 932 Chinese individuals (464 nAMD patients and 468 ...
متن کاملRisk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration.
PURPOSE Systemic complement activation is associated with age-related macular degeneration (AMD) and has mainly been attributed to a risk allele in the complement factor H (CFH) gene. Whether other important AMD genes also influence complement activation is unclear. In the present case-control study, complement activity and concentrations of complement components and their activation products a...
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ژورنال
عنوان ژورنال: Biomedical Journal of Scientific and Technical Research
سال: 2023
ISSN: ['2574-1241']
DOI: https://doi.org/10.26717/bjstr.2023.49.007855